Abstract: . . .  Conjugation of protein to immunostimulatory DNA results in a rapid, long- lasting and potent induction of cell-mediated and humoral immunity. Eur J Immunol (2000) 30 :1939-1947. 27. Cho HJ, Takabayashi K, Cheng P-M, Ngyuyen M-D, Corr M, Tuck S, Raz E: Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nature Biotechnol (2000) 18 :509-514. 28. Tighe H, Takabayashi K, Schwartz D, Van Nest G, Tuck S, Eiden JJ, Kagey-Sobotka A, Creticos PS, Lichtenstein LM, Spiegelberg HL, . . .
. . .  KH: Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Med (1996) 2 :540-544. Page 8 DNA-based approaches to the treatment of allergies Spiegelberg & Raz 71 21. Lee DJ, Tighe H, Corr M, Roman M, Carson DA, Spiegelberg HL, Raz E: Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T- cells. Int Arch Allergy Immunol . . .
. . .  Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur J Immunol (2000) 30 :1841-1850. This paper demonstrates the effect of ISS-ODN on both immediate and late-phase allergic conjunctivitis in the mouse .  . . .
. . .  Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Med (1996) 2 :540-544. Page 8 DNA-based approaches to the treatment of allergies Spiegelberg & Raz 71 21. Lee DJ, Tighe H, Corr M, Roman M, Carson DA, Spiegelberg HL, Raz E: Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T- cells. Int Arch Allergy Immunol (1997) 113 . . .
. . .  of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Med (1996) 2 :540-544. Page 8 DNA-based approaches to the treatment of allergies Spiegelberg & Raz 71 21. Lee DJ, Tighe H, Corr M, Roman M, Carson DA, Spiegelberg HL, Raz E: Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T- cells. Int Arch Allergy Immunol (1997) 113 :227-230. 22. . . .
--3000,5,300,3096,44989