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Abstract. . .  antigen-induced airway hyperresponsiveness. Ann Rev Immunol 1999, 17: 255281. This review covers many mechanisms that may lead to bronchial hyperresponsiveness. 64. Voynow JA, Selby DM, Rose MC: Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis , and normal individuals. Lung 1998, 176: 345354. 65. Voynow JA, Young LR, Wang Y, et al. : Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999, 276: L835L843. 66. Yuta A, Baraniuk JN: Therapeutic approaches to airway mucous hypersecretion. In Airway Mucus: Basic Mechanisms and Clinical Perspectives: Respiratory Pharmacology and Pharma- cotherapy series. Edited by Rogers DF, Lethem MI. Basel: Birkhauser; 1997:365383. 67. Ziment I: Historic overview of mucoactive drugs. In Drugs in Bronchial Mucology. Edited by Braga PC, Allegra L. New York: Raven; 1989:134. 68. Claman DM, Bousher HA, Lui J, et al. : Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994, 94: 861869. 69. Baroody FM, Cruz AA, Lichtenstein LM, et al. : Intranasal beclomethasone inhibits antigen induced nasal hyperresponsiveness to histamine. . . .
. . .  1992, 90: 373376. 70. White MV: Nasal cholinergic hyperresponsiveness in atopic subjects studied out of season. J Allergy Clin Immunol 1993, 92: 278287. 71. Figueroa JM, Mansilla E, Suburo AM: Innervation of nasal turbinate blood vessels in rhinitic and nonrhinitic children. Am J Respir Crit Care Med 1998 157: 19591566. The innervation of human nasal mucosa is displayed in precise photomicrographs. 72. Fang SY, Shen CL: Neuropeptidergic innervation of human nasal mucosa in various pathological conditions. Proc Natl Sci Counc Repub China B 1997, 21: 812. 73. Fang SY, Shen CL: Neuropeptide innervation and neuro- endocrine cells in allergic rhinitis and chronic hypertrophic rhinitis . Clin Exp Allergy 1998, 28: 228232. 74. Druce HM, Wright RH, Kossoff D, Kaliner MA: Cholinergic nasal hyperreactivity in atopic subjects. J Allergy Clin Immunol 1985, 76: 445452. 75. Kurian SS, Blank MA, Sheppard MN: Vasoactive intestinal polypeptide (VIP) in vasomotor rhinitis . Clin Biochem 1983, 11: 425426. 76. Lucchini RE, Facchini F, Turato G, et al. : Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis. Am J Respir Crit Care Med 1997, 156: 19631968. 77. Einarsson O, Geba GP, Zhou Z, et al. : Interleukin-11 in respiratory . . .
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