Abstract: . . .  minophen in aspirin-sensitive subjects with asthma. J Allergy Clin Immunol 1989; 84:2633. 30. Eneli I, Sadri K, Camargo C Jr, Barr RG. Acetaminophen and the risk of asthma: the epidemiologic and pathophys- iologic evidence. Chest 2005; 127:604612. 31. Simon RA. Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs. Curr Allergy Asthma Rep 2004; 4:1724. 32. Stevenson DD, Simon RA. Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. J Allergy Clin Immunol 2001; 108:4751. 33. Szczeklik A, Nizankowska E, Bochenek G, Nagraba K, Mejza F, Swierczynska M. Safety of a specific COX-2 inhibitor in aspirin-induced . . .
. . .  CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 73 NUMBER 7 JULY 2006 671 CRISTINE RADOJICIC, MD Section of Allergy, Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic Sinusitis: Allergies , antibiotics, aspirin, asthma REVIEW ABSTRACT Sinusitis is very common, so it is important to understand its pathophysiology, diagnosis, and medical and surgical treatments. In cases of chronic sinusitis, adjunctive therapies and evaluation by subspecialists may be warranted. Some special testing is needed to . . .
. . .  Immunol 1990; 85:5965. 38. Israel E, Fischer AR, Rosenberg MA, et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensi- tive asthmatics to aspirin. Am Rev Respir Dis 1993; 148:14471451. 39. Dahlen B, Nizankowska E, Szczeklik A, et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conven- tional therapy in aspirin-intolerant asthmatics. Am J Respir Crit Care Med 1998; 157:11871194. ADDRESS: Christine Radojicic, MD, Department of Pulmonary, Allergy, and Critical Care Medicine, C22, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail radojic@ccf.org. 678 CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 73 NUMBER . . .
. . .  the upper airway disease as well as the lower airway disease of patients with asthma, it can significantly improve refractory symptoms of recurrent polyps and chronic sinusitis. 37 Nasal steroids should be used aggressive- ly to shrink polyps and possibly to prevent their regrowth after surgical polypectomy. Although surgical removal of polyps may improve nasal and sinus symptoms and decrease the occurrence of sinus infections, polyps almost always recur. Prolonged antibiotic therapy is often necessary for adequate resolution of chronic sinus infections in aspirin-sensitive patients. Inhibitors of leukotriene synthesis (eg, zileuton)  . . .
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